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Chem 5253
ORGANIC CHEMISTRY Fall 2011
Biology Students
Click
her for Faculty Calendar
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Instructor:
Professor Mohamed EL-Fellah
Office: 111 Chemistry Building
Website:
www.el-fellah.com
E-Mail: mohamed_194917@yahoo.co.uk
Office Hours: Sunday 12:00 – 13:00 pm
Monday 12:00 – 13:00 pm (or by appointment)
Classes:
TR @ 12 – 13:30 pm Group A in Faculty Building
( 2
FRB)
TR @ 12 – 13:30 pm Group C in Faculty Building (5 FRB)
T= Time
& R= Class Room |
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Instructor:
Mr. Mohammed G. EL-Arfi
Office: 136 Chemistry Building
Office Hours: Sunday 10:00 – 12:00 pm
(or by appointment)
Classes:
TR @ 012:00 – 2:00 pm Group A1 in
Faculty Building
( 6 FRB)
TR @ 03:00 – 5:00 pm Group B in
Faculty Building
( 2 FRB)
TR @ 10:00 –12:00 pm Group D in
Chemistry Building
(245 CB)
T= Time &
R= Class Room , C= Chemistry
Building
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Materials:
Organic Chemistry, by
1- Morrison & Boyd
2- John McMurry
Note:
All electronic devices are
not
allowed
during class. Please turn your cell phones/ringers off and avoid activity
that will distract your classmates.
Chem 5253
Course Description:
Organic Chemistry
explores the structure of organic materials, the physical properties defined
by these structures, and the manner in which
we can manipulate materials by
altering their structure. This course will focus specifically on the
structure, properties, bonding, stereochemistry, reactions, and reaction
mechanisms of carbon based molecules (see Course Sequence for more details).
Course Goals:
In the Curriculum:
CHEM-5253 is intended for students majoring in, Biology , or
Engineering .
By the end of this course,
you should
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Be able to identify
the major functional groups, and find them
in a structural representation of any
organic compound.
-
Be able to give a
systematic name to any simple organic
compound.
-
Have a practical
understanding of how structure influences
reactivity.
-
Know several organic
reactions and be able to use them to build
organic molecules from simple precursors
("organic synthesis").
-
Communicate the structure of molecules to others via IUPAC nomenclature
and depict the structure when given the name of a molecule.
-
Understand the three dimensional structure of molecules and be able to
represent
these structures by conventional means.
-
Account for the physical properties and chemical reactivity of any organic
compound on the basis of molecular structure.
-
Predict the outcome of an organic reaction, when given substrates and
reagents, or
provide adequate reagents to convert starting materials to desired products.
-
One of the goals of the
course is to encourage students to ask
questions. Asking should never embarrass the
student who asks, even when the question might
embarrass the teacher. If you don't understand
something, it is likely that others don't
understand either but haven't realized it yet or
are too shy to ask. The teacher may not have
explained clearly, or perhaps hasn't thought
about the subject carefully enough.
Goals for Your Future:
• Develop your study skills; memorization is not
sufficient for this class.
• Learn to combine the association of ideas and
relationships with deductive reasoning and
scientific method to solve problems (Chemistry
problems and others).
• Gain an informed view of Chemistry’s impact
on our quality of life.
• Understand Chemistry’s relationship with other
sciences.
Course Sequence:
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Topics
Requirements
a)
Alkanes and Cycloalkanes
Sp3–hybridization.
Structural
Isomerism &Geometric isomerism.
Synthesis
[halogenations of alkanes, addition of
HX to alkenes and alkynes, from alcohol
( SOCl2 , PX3, PX5)].
Reactions
(nucleophilic substitution, elimination,
Grignard’s reagent, reduction by metal
and acids)
b)
Alkenes and Cycloalkenes
Sp2–hybridization,
physical properties (boiling points,
solubility
Nomenclature
(common, IUPAC).
Geometric
isomerism.
Synthesis [dehydrohalogenation
of alkyl halides, dehydration of
alcohols].
Reaction
[halogenations, hydrogenation, addition
of hydrogen halides, halohydrin
formation, oxidation, epoxidation,
ozonololysis].
c) Alkynes and
Cycloalkynes(3 lectures)
Sp–hybridization,
Nomenclature (common, IUPAC).
Physical
properties (boiling points, solubility),
Synthesis [from CaC2,
dehydrohalogenation of alkyl halides,
from sodiumacetylides],Reaction
[hydrogenation, addition of HX, H2O,
X2].
Alkyl groups
(Click her)
Nomenclature (common, IUPAC).
Physical
properties & Synthesis.
Reaction.
Benzene and aromatic
compounds.
Structure and
stability of benzene, aromatic
character, Nomenclature.
Nomenclature
(continue), reactions [aromatic(
halogenations, alkylation's, nitration,
s ulphonation)
Side chain
reaction (halogenations of alkyl side
chain, oxidation & nitration).
Synthesis
[halogenations of alkanes, addition of
HX to alkenes and alkynes, from alcohol
( SOCl2 , PX3, PX5)].
Reactions
(nucleophilic substitution, elimination,
Grignard’s reagent, reduction by metal
and acids)
Oxygen containing
compounds
(Click her)
a)Alcohol, Phenol,
Ether, Epoxides&Alcohol
Classification,
structure, nomenclature (common, IUPAC),
physical properties (solubility,
hydrogen bonds, b.p),
Synthesis of
alcohols (review from alkenes and alkyl
halides, Grignard reagent with
aldehydes , ketones and esters,
reduction of aldehydes, ketones , acids
and esters).
Reaction of
alcohols (salt formation, oxidation,
ester formation.
Phenol
Structure,
nomenclature (common, IUPAC) physical
properties (boiling point& acidity).
Synthesis of
phenols (hydrolysis of diazonium salt,
alkali fusion, of sodium
benzenesulfonates). Reaction of phenol
(salt formation, oxidation, ester
formation).
Ether& Epoxides
Structure,
nomenclature (common, IUPAC), Synthesis
of ether (dehydration of alcohols,
William synthesis of epoxide, synthesis
from alkenes and alcohol, reaction of
ethers (with HI, reaction of
epoxide (three member ring ) with H2O,
ROH, HX, LiAlH4, phenol, Grignard
reagent.
b) Aldehyde and
ketones
(Click her)
Structure,
nomenclature (common, IUPAC).
physical
properties (solubility, b.p),
synthesis [ oxidation of alcohols,
ozonolysis of alkenes, hydration of
alkynes, hydrolysis of alkyl dihalides].
reaction of
aldehyde and ketones [ reaction of
carbonyl compounds, addition of Grignard
reagent, addition of alkynide ions,
addition of HCN. Addition of
alcohol,(hemiacetal, cital, hemiketal,
and ketal formation, no mechanism)
Addition of
ammonia and its derivatives, synthesis
of amino acids , acidity of aldehydes
and ketones, aldol condensation.
c) Carboxylic acids
(Click her)
and it's derivatives
(Click her)
.
Structure,
nomenclature (common, IUPAC), physical
properties (solubility, b.p & acidity),
Synthesis [
oxidation of Aldehydes], carbonation of
Grignard reagent, hydrolysis of nitrile,
and carbonation of acetylene.
Reaction of
carboxylic acid( salt formation,
formation of acid derivatives: acid
chloride, acid anhydride, amide, ester.
Nomenclature of acid derivatives
Reaction of acid
derivatives [elimination reaction,
hydrolysis of acid chloride, ester,
reaction with acid chloride, acetylation
, reduction.
Nitrogen-containing
compounds
(Click her)
Classification,
structure, nomenclature common, IUPAC),
physical properties (solubility,
hydrogen bonds, b.pts), basicity of
aliphatic amine and aniline, quaternary
ammonium salt,
Synthesis, of
amines[ reduction of nitro, nitrile,
oxime, amide, alkylation of ammonia],
Reaction [salt
formation, alkylation, reaction with
nitrous acid,
amide formation. |
Grading:
Instructor’s
Grading Philosophy:
“STUDENTS
EARN GRADES, I
DOES NOT GIVE GRADES.”
Self-Assessment:
Work the problems within and at the end of each
chapter. I will allow time in class for questions
regarding problems (YOU MUST PROVIDE THE QUESTIONS),
or you can visit me at office hours when time is not
available in class. Please have a specific question
if you plan on visiting.
Course Policies:
Class Preparation:
You are expected to read ahead for this class. You
will be asked to review material that is not covered
in detail during class. You are responsible for
understanding this material as it pertains to future
lessons and your exams. My role during class is to
enhance understanding, tie together themes and
ideas, and teach you how to learn organic
chemistry.
Working through problems in the book will point out
areas that you need to review for better
comprehension (See Self-Assessment). If you
are prepared for class, then you will be able to ask
questions in areas that will benefit your
comprehension greatest. If you test yourself against
problems in the book, you will know how to focus
your test preparation time.
Hints on how to do well in this
class:
During class: Attend classes and compile a
thorough set of lecture notes; participate in
learning activities. Don't be embarrassed to ask
questions or ask instructors to repeat material.
After lecture: Review your notes and read
the relevant text sections again. With the use
of your text, be sure that you understood the
class material.
Attendance:
Your book, like your instructor, does not have all
the answers. Unfortunately, the text cannot restate
an idea if it is unclear. You are expected to ask
and answer questions encountered in class and from
your homework. Material from these class discussions
may be emphasized on exams. Attendance is necessary
for success in this course. No make up quizzes will
be given. Late homework will not be accepted.
Exams:
First Hour Exam will be in :
Sunday 25 /12/2011 ( All Groups)
Second Hour Exam Sunday 29 /01/2012
( All Groups)
The Final Exam
will be in Saturday the second week of the final
exam could be in 25/02/2012.
 
تمنياتي لكم
جميعا بعام رائع وموفق من الله
أ.د. محمد
فرج الفلاح
أ. محمد
جبريل العرفى
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